5Amino-1MQ
   

5Amino-1MQ

5-Amino-1MQ

5-Amino-1MQ is a synthetic methylquinolinium derivative designed as a potent inhibitor of nicotinamide N-methyltransferase (NNMT).

  • Batch tested Purity: ≥ 98 % (HPLC, typical)
  • CAS Number: 42464-96-0
  • Molecular Formula: C₁₀H₁₁N₂⁺

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5-Amino-1MQ

Synonyms / Designations: 5-Amino-1-methylquinolinium, 5-Amino-1-MQ, NNMT inhibitor analog
CAS Number: 42464-96-0
Molecular Formula: C10H11N2+ (monocationic quaternary ammonium)
Molecular Weight: ~159.21 g/mol
Purity: ≥ 98 % (HPLC, typical)
Appearance: Off-white to pale yellow crystalline powder
Pack Size: 10 mg (total)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in water, dilute acids; soluble in polar aprotic solvents (e.g. DMSO)

Description & Mechanism

5-Amino-1MQ is a synthetic methylquinolinium derivative designed as a potent inhibitor of nicotinamide N-methyltransferase (NNMT). In biochemical research systems, it modulates metabolic signaling by interfering with NNMT catalytic activity, thereby influencing levels of methylated nicotinamide derivatives and related metabolites. Peptide Sciences+1

NNMT is a cytosolic enzyme that catalyzes methyl transfer from S-adenosyl methionine (SAM) to nicotinamide and related substrates. Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues. Peptide Sciences

In preclinical biochemical settings, inhibition of NNMT by compounds like 5-Amino-1MQ leads to alterations in intracellular NAD⁺ salvage pathways, shifts in methyl donor balance, and downstream metabolic signaling changes. Peptide Sciences

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